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Factoring in the average number of cigarettes smoked per day, the authors write that this would lead to an increase in the estimated loss of life expectancy per cigarette to 20 minutes overall: 17 minutes for men and 22 minutes for women. Though its arguably an improvement upon the earlier study, the authors of the new study are careful to note that their research also has caveats, the main one being that the estimate is based on averages such as of smoking pattern and type across populations and ages

There were no significant interactions between the PRS and the smoking status or pack-years