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The origin from Etymonline indicates: 1888, probably from fag "loose piece, last remnant of cloth" (late 14c., as in fag-end "extreme end, loose piece," 1610s) This appears to be speculative, and doesn't necessarily explain why this definition fell into common usage to indicate a cigarette

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I hope the results of this study can reach at least some smokers of Natural American Spirit cigarettes and help in correcting the misperception that these cigarettes are somehow healthier than other brands. This study was supported by the National Cancer Institute of the National Institutes of Health and the Center for Tobacco Products of the Food and Drug Administration, and by a Continuing Umbrella of Research Experiences supplement from the National Cancer Institute

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