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Ethics statement All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Boards at the Johns Hopkins Bloomberg School of Public Health (#8817) and at the Instituto Nacional de Salud Pblica (#1582) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards

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New-generation EC devices were more efficient in nicotine delivery, but still delivered nicotine much slower compared to tobacco cigarettes