zhonghua cigarette Smoking: Effects, Risks, Diseases, Quitting & Solutions Surprising Ways Smoking Affects Your

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Human smokers build up a bit of a tolerance to nicotine, which mitigates some of the negative side effects

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Chronic nicotine use dysregulates this system, increasing stress sensitivity and emotional instability over time. Additionally, Mendelian randomization studies have found causal evidence that smoking increases the risk of developing depression and even schizophrenia, rather than simply being a consequence of them. This supports the view that smoking may not only sustain but also exacerbate or even initiate mood disorders in vulnerable individuals