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Indeed research based on the theory of planned behavior among adolescents has indicated that graphic warning labels are regarded by adolescents as more effective in preventing them from smoking, and in informing them about the health effects of smoking, in comparison to text-only warnings [13]

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1 Introduction Adolescence is a period of brain development during which neurotransmitter systems are actively maturing, with dopamine (DA) exhibiting particularly dynamic changes ( Among teenagers, recreational use of electronic nicotine delivery systems (e-cigarettes) has escalated exponentially ( Initiation of smoking typically occurs during adolescence, with approximately 90% of adult smokers starting before age 18 ( Adolescent rodents, conservatively defined as between postnatal day (P) 28 and 42 ( In adolescent rodents, but not adults, brief exposure to nicotine enhances cocaine locomotor sensitization, conditioned place preference, and self-administration as well as quinpirole-induced activity ( 1A receptor (5-HT 1A R) antagonist ( 1A R signaling during adolescence may underlie enhanced behavioral sensitivity to DA drugs after nicotine exposure