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Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas

From 2.43 per 100000 in 1990 to 1.65 per 100000 in 2007, the ASMR steadily decreased to 1.44 per 100000 in 2021, after stabilizing at 1.66 per 100000 from 2008 to 2012 (Figure 1A)

Clinical examination Full skin examination assess for hyperextensibility of the skin and abnormal scarring The Beighton scale assess for hypermobility of a joint, in which a score of 5 or more indicates generalised joint hypermobility Investigations Skin biopsy for histology, fibroblast culture, and electron microscopy When suspecting kyphoscoliotic EDS, a urine sample is taken to measure the ratio of lysyl-pyridinoline to hydroxylysyl-pyridinoline cross-links Molecular genetic testing confirms the diagnosis, except in the case of hypermobile EDS, which has an unknown genetic basis and so is a clinical diagnosis which must meet all the clinical criteria