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Cigarettes are essentially nicotine delivery packages

Abnormal regional brain activity has been revealed in mesolimbic dopamine reward circuits, including the ventral tegmental area, nucleus accumbens, hippocampus, amygdala, cingulate, thalamus, striatum, and prefrontal cortex, as well as visuospatial attention circuits, including the dorsolateral and ventrolateral prefrontal cortex, parietal cortex, and extra-striate visual cortex in smokers 15, 16

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Although self-reported smoking yields lower prevalence estimates than assessment with serum cotinine, a metabolite of nicotine, it is unlikely that underreporting will have a large effect on the findings of this report because of the overall high concordance between self-reported smoking and biochemical assessment with cotinine ( 7 )