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Given the above considerations, we conducted a randomized controlled trial (RCT) to examine, in COPD patients receiving regular 12-week varenicline therapy, whether using varenicline for a 6-week gradual cessation before the target quit day (TQD), rather than starting 1 week before the TQD as currently labeled, would improve quit outcomes 30 weeks after randomization

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As well, since a panel of biomarkers consisting of CEA, CA125, CYFRA 211 and Pro-SFTPB was recently found to be highly predictive of smokers subsequently developing lung cancer 19 , we were interested in determining their values

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