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For that group, treating the deficiency is important, because an untreated deficiency does not stay still

Pregnancy and breastfeeding status should be disclosed, as B12 is generally safe but individual circumstances require clinical judgment

They also have an impact on NAMPT levels 6 , which fluctuate to meet cellular NAD+ demand

Further, the conversion of both hydroxycobalamin and cyanocobalamin to the active Adenosyl and methyl cobalamins, also involve "Flavoproteins" (Obeid etal, 2015) and hence if a person takes or is injected with, high doses of hydroxycobalamin or cyanocobalamin and has functional B2 deficiency, the inactive hydroxycobalamin and cyanocobalamin will accumulate in serum, however the symptoms of vitamin B12 deficiency will not be resolved