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There was and there still is no other regulatory agency in the world with these authorities and responsibilities, Zeller said in an interview

The absence of a longitudinal follow-up limits the ability to track the progression of OSMF and other oral lesions over time, establish temporal relationships between risk factors (e.g., areca nut use) and lesion development and assess outcomes such as lesion regression or malignant transformation

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These patients are at the highest risk of relapse