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When he was cast as machinist Trevor Reznik for the 2004 movie 'The Machinist' who was emaciated due to his insomnia, the star set himself a target of slashing his weight from 182lbs to just 120lbs

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"He would subject them to extreme temperatures, make them go hungry for long periods, or make them exercise a lot," the medical historian Mark Jackson says

Additionally, the upregulation of FUNDC1 was observed in the liver tissues of mice and patients with liver fibrosis, and it induced liver injury by promoting mitophagy-dependent ferroptosis in hepatocytes