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Besides, protein undergoes carbonylation, another form of protein oxidative modification in which ROS groups bind to specific amino acids, affecting protein stability and activity ( Furthermore, ROS/RNS can directly attack DNA, causing oxidative DNA damage in IBD ( 2.3 Mitochondrial dysfunction Mitochondria, with their functions in energy production, calcium homeostasis, and membrane excitability, are thought to substantially impact the pathology of IBD, as their dysfunction may initiate and advance the disease

On the contrary, nine variant exons (exons 614 or v2-v10), located in the middle of the CD44 gene can be alternatively spliced and assembled with exons contained in CD44s, resulting in the formation of a plethora of CD44 variant isoforms, typical of cells of epithelial origin and several carcinomas

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

10.1021/jo801198u 223 QiS