Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4) oregon green a synthetic antibiotic
Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4) oregon green a synthetic antibioticSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX
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