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The core pathology of FXS revolves around the expansion of CGG repeats within the FMR1 gene, which triggers DNA methylation and subsequent gene silencing (216)

This new approach is very different from the traditional chemical characterization techniques, as it is typically targeted, therefore able to characterize only a single class of compounds or a single metabolite, defined a priori

PoDs were defined as the concentration at which the mean response to a test material exceeded the 95% credible range of control for each timepoint (otherwise the mean response remains within the range of control)

Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice