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Nutritional psychiatry suggests that the diet quality could be a modifiable risk factor, with evidence linking diet to mental health via pathways such as inflammation, oxidative stress, the gut microbiome, and neuroplasticity ( A systematic review in 2017 of RCTs found that adjunctive vitamin B supplementation, particularly B6, B8, and B12, significantly reduced psychiatric symptoms in people with schizophrenia compared with placebo, although effects on the specific symptom domains (positive and negative) were not observed ( Our systematic review revealed mixed findings regarding whether anti-inflammatory diets and supplementation of omega-3 fatty acids, fish oil, and vitamin D are effective in the treatment of metabolic markers or schizophrenia symptoms

( i ) Percent change in body weight at endpoint (Day 26) compared to weight at tumor cell injection (Day 0)

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May cause drowsiness or dizziness