While Nos-2 levels were similar in 3 month C57 and DBA retinas (p = 0.51) and in 10 month C57 and DBA retinas (p = 0.52), a 341% increase was observed in DBA retinas at 7 months of age compared to C57 mice (*p 0.72), while a 211% increase was observed in 10 month DBA retinas (p = 0.003), which resulted in a 106% increase in GFAP in DBA retinas at this age (*p 0.21), but increased significantly in 7 and 10 month DBA retinas respectively (p 0.13) and DBA retinas (316%
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Clinical trials, such as SYDNEY-2 and NATHAN 1, found that taking 600 to 1,200 mg daily improved nerve blood flow and reduced symptoms of neuropathy over several months or years (Ziegler et al., 2006
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