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The clear solutions were analysed on an Agilent 1290 HPLC system with a binary pump, multisampler, and column thermostat with a Zorbax Eclipse C-18, 3.0 50 mm, 1.8 m column using methanol/2-propanol

In agreement with earlier research, our findings demonstrated that abemaciclib triggers the endoplasmic reticulum (ER) stress response, modifies the mitochondrial membrane potential, and consequently causes loss of membrane integrity, cytochrome c release, ROS generation, cellular endogenous antioxidant depletion, caspase activation, pro-apoptogenic proteins BAX and P53 upregulation, and anti-apoptogenic protein Bcl-2 downregulation

Content : 250 ml FDA Registration Number : 10-1-5440175