Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-PNP featured It features a disulfide bond

It features a disulfide bond

127 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-acetamido-PEG2-propargyl Synonyms Thalidomide-4'-O-acetamido-PEG2-propargyl CAS Number n/a Related CAS Molecular Formula C22H23N3O8 Molecular Weight 457

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-PNP featured It features a disulfide bondSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as