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Feature · Product Review

Fmoc-Val-Cit-PAB dsa 3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5

Fmoc-Val-Cit-PAB dsa 3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5Fmoc Val Cit PAB is a cleavable ADC linker featuring a ValCit dipeptide and a para aminobenzyl (PAB) spacer. The ValCit sequence is selectively cleaved by cathepsin B in lysosomes, while the para aminobenzyl (PAB) spacer supports self immolative release of the attached drug, and the Fmoc protecting group can be removed to enable further functionalization or conjugation. Product Name Fmoc Val Cit PAB Synonyms Fmoc VC PAB OH CAS Number 159858 22 7

SKU: 32352828678 · From www.marsberger-treibhaus.de

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Description

3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5

S)-AHPC-CO-PEG6-C2-acid Synonyms CAS Number n/a Related CAS Molecular Formula C27H34N4O4S Molecular Weight 510

Nitrogen Heterocycle Based Linker (NHBL)

by coordinating through its four nitrogens and four carboxylate oxygen atoms

Fmoc-Val-Cit-PAB dsa 3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5Fmoc Val Cit PAB is a cleavable ADC linker featuring a ValCit dipeptide and a para aminobenzyl (PAB) spacer. The ValCit sequence is selectively cleaved by cathepsin B in lysosomes, while the para aminobenzyl (PAB) spacer supports self immolative release of the attached drug, and the Fmoc protecting group can be removed to enable further functionalization or conjugation. Product Name Fmoc Val Cit PAB Synonyms Fmoc VC PAB OH CAS Number 159858 22 7

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