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Diarrhea, nausea, and vomiting occurred more frequently during dose escalation and declined gradually over time

We conducted titration experiments on the complex of 15 N-labeled p53 TAD (13-61) and unlabeled FOXO4 FHD with increasing concentrations of p53 TAD PEP

That, however, disregards the fact that alternative enzymatic pathways exist that may allow the synthesis of the smaller, later angiotensin peptides despite blockade of enzymes like ACE [6], and that the brain possesses a complete renin-angiotensin system that may be affected differently by therapeutic agents with limited ability to cross the blood brain barrier than the peripheral renin-angiotensin system [7]

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