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de Rothschild, Paris, France, 10 Neurology Department, Hpital Lariboisire, Paris, France, 11 Universit Paris Cit, Paris, France, 12 INSERM, U1144, Paris, France, 13 FHU NeuroVasc, Paris, France, 14 Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France, 15 Department of Diagnostic and Therapeutic Neuroradiology, Universit de Lorraine, CHRU-Nancy, Nancy, France, 16 Universit de Lorraine, INSERM 1254, IADI, Nancy, France Background and Aims: Time from symptom onset to puncture (TSOP) and time from puncture to reperfusion (TPTR) are associated with worse outcome in ischemic stroke patients treated with endovascular therapy (EVT) in the early window ( 6 h), where EVT may benefit patients with favorable imaging profiles is unknown (late window paradox)

Agents targeting bile acid homeostasis Dysregulated bile acid metabolism contributes to liver injury and disrupts lipid homeostasis, correlating with disease severity in SAH

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Genetics also play a role, making some prone to pigmentation, while aging reduces the skins ability to repair, causing persistent pigmentation over time