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Western blot analysis revealed that 13 of 63 subjects with ASD possessed autoantibodies that demonstrated specific reactivity to a cerebellar protein

[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing