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Supplementary Materials The following supporting information can be downloaded at: Figure S1: 3D structure of bovine xanthine oxidase (XO), protein cleaved form

An explanation of how we came to these new recommendations can be found in Vitamin B12: Rationale for Recommendations

Based on the evidence provided by Evidence Development and Standards and its partners, the Ontario Health Technology Advisory Committeea standing advisory subcommittee of the Health Quality Ontario Boardmakes recommendations about the uptake, diffusion, distribution, or removal of health interventions to Ontarios Ministry of Health and Long-Term Care, clinicians, health system leaders, and policy-makers

Generally, physicians dont recommend spinal stenosis surgery unless patients have undergone six to 12 months of non-surgical treatment without symptom improvement