Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg PROTACs and Molecular Glues as

PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase

877 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC(O)=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

79 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N+]=[N-])=[N+](C)C)=C2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons

Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg PROTACs and Molecular Glues asSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate