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In vivo studies have shown that S1P expression is increased and associated with pulmonary resistance in cigarette smoke-induced COPD mice [93]

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Transport Secretary Grant Shapps said Ms Rayner's verbal attack was 'absolutely appalling', telling Sky News: 'There's no place in public life for that sort of language, that sort of behaviour.' But veteran Tory MP James Gray also opened up the Conservatives to criticism after he suggested a bomb should be planted in Labour frontbencher Anneliese Dodd's office