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In summary, with these experiments, we demonstrated that an increase in TGFb signaling via treatment with TGFb ligands exacerbates toxicity in aSyn-overexpressing cells, and this detrimental effect can be mitigated through the knockdown of ALK5 , SMAD2 , and DYNLRB1

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With a higher frequency of double-rooted origins and multiple insertion points at lower levels, the distribution patterns of SVN are consistent across spinal levels