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However, iron chelators are relatively small molecules compared with proteins, and no significant neurotoxicity or immunogenicity due to IN DFO has been reported

In addition to the basic genotypes outlined below, certain specialized strains are available to confer greater transcriptional control, assist with proper protein folding, and deal with sub-optimal codon usage (Table 1) A few mutations are common to all or most expression strains to accommodate high protein levels including: ompT: Strains harboring this mutation are deficient in outer membrane protease VII, which reduces proteolysis of the expressed recombinant proteins

It is a well-characterized molecule with a substantial research base