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Side Effects & Safety Nausea 44% in STEP trials, most common side effect, dose-dependent Diarrhea 30% in trials Vomiting 24% in trials Constipation 24% in trials Stomach pain 20% in trials Pancreatitis rare but documented

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Interestingly, RS cells expressed c-MET but not HGF and several HGF-positive dendritic-reticulum cells were found scattered around c-MET-positive RS cells [47]

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