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Collectively, to systematically investigate tissue- and cell-type-specific expression profiles of E3 Ub ligases, under normal or diseased/stressed states, will be an attracting topic in the next decade either to comprehensively understand the biology of E3 ligases in different diseases/stresses or to extend PROTAC applications

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In one clinical experiment, patients treated with NAC had higher multivariate phase synchronisation, which changed neuron connectivity in the brain, as evaluated by an electroencephalogram, even before any clinically noticeable improvement [36]

Choi et al., 2016, reported that piceatannol (a resveratrol metabolite found in red wine) affected HDAC expression in a mouse model and concluded that it may be a valuable therapeutic agent in renal fibrosis by decreasing HDAC4 and HDAC5 protein expression [264]