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coli O55:B5 could activate most of microglia in the rat brain microvascular endothelial cell (RBEC)/microglial co-culture system at 6 hours, which appeared as a morphological change from round to bipolar rod shape with enlarged cytoplasm and cell bodies, and an enhanced ionized calcium binding adapter molecule 1 (Iba1) staining (Nishioku et al., 2009

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Moreover, it is not clear whether the ability of GSHee to blunt the ventilatory depressant effects of fentanyl is due to enhancement of GSH and cysteine levels in relevant tissues such as the brainstem and carotid bodies