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The mixed effects ANCOVA model was specified as follows:where, observed [ex: (AUEC or E max )] overall mean effect of the i th investigational product (IP), a fixed effect effect of the j th sequence, a fixed effect effect of the k th period, fixed effect common slope of baseline UTS, a continuous covariate

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But the federal government hasn't brought them in, citing concerns the ban could trigger an illicit market a common argument also made by nicotine lobbyists