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The antibodies can be used diagnostically to, for example, monitor the development or progression of a tumor as part of a clinical testing procedure to, e.g., determine the efficacy of a given treatment regimen

Other proposed mechanisms include direct interaction with cell surface integrins (particularly alpha-2-beta-1), effects on iron metabolism through copper-iron regulatory interactions, and epigenetic modifications

However, kidneys can be quite sensitive to additional substances we introduce into the body, especially if there is already some kidney dysfunction present

Rajagopal Sekhar, associate professor of medicine in the Section of Endocrinology, Diabetes and Metabolism at Baylor