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Standardize SCFAssampling sites and quantitative platforms (reporting feces/cecum/serum separately) and supplement with blood/tissue exposure data to avoid the implicit leap that fecal content systemic exposure. Use longitudinal time sampling (early/mid-term/late stage) to see whether the changes of SCFAs preced inflammation remission, so as to reduce the misunderstanding of causal inversion

The through line of history is that people will try to sell anything with all sorts of fantastical claims, Joshua Sharfstein, a health-policy professor at Johns Hopkins and a former principal deputy commissioner of the F.D.A., told me