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Bei den Hufigkeitsangaben zu Nebenwirkungen werden folgende Kategorien zugrunde gelegt: Sehr hufig: kann mehr als 1 von 10 Behandelten betreffen Hufig: kann bis zu 1 von 10 Behandelten betreffen Gelegentlich: kann bis zu 1 von 100 Behandelten betreffen Selten: kann bis zu 1 von 1.000 Behandelten betreffen Sehr selten: kann bis zu 1 von 10.000 Behandelten betreffen Nicht bekannt: Hufi gkeit auf Grundlage der verfgbaren Daten nicht abschtzbar

A good example of this is given by flutamide, an antiandrogen used in the treatment of prostatic carcinoma, which undergoes substantial metabolism in vivo with hydrolysis of the amide bond liberating 3-trifluoromethyl-4-nitroaniline

Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells

To compare AfCycDesign-generated sequences to sequences designed by ProteinMPNN, we we also designed sequences of 22,182 10 residue hallucinated backbones using ProteinMPNN 32 and compared the pLDDT of peptides designed by both methods (Supplementary Fig