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By bilaterally injecting lentiviral vectors carrying siRNA targeting GSK-3 into the hippocampal dentate gyrus region to modulate GSK-3 activity, the study found that IF promoted neuronal differentiation and maturation in the dentate gyrus and improved the known dysfunction in 3xTg-AD mice

Statins enhance NO bioavailability by decreasing NADPH oxidase activity in a Rac1-dependent manner, reducing caveolin-1 activity, decreasing asymmetric dimethyl-l-arginine, improving activating eNOS phosphorylation, and upregulating eNOS mRNA (196)

For the shallow-desensitized state, focused masks around the ATD and LBD-TMD regions were created separately and used for local refinements of the corresponding regions

2024 Jul 10];9