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Indeed, loss of glutathione peroxidase 4, a oxidation-resistant selenoprotein that utilizes GSH, leads to lipid peroxidation and subsequent ferroptosis, which is also found in epilepsy models ( The NADPH oxidase (NOX) family of enzymes is another relevant major source of ROS in the context of epilepsy as evidenced by activation of NOX2 by kainate-induced SE (Patel et al., 2005)

Smith AG, Singleton JR

The HPPD family was identified based on the presence of the PLN02875 domain, a characteristic domain of 4-hydroxyphenylpyruvate dioxygenase

Moreover, PI3K/AKT/mTOR oncogenic cascade pathways are frequently dysregulated in several types of cancer, further enhancing lipogenic activities