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GSSG extrusion into bile helps to maintain the intracellular GSH/GSSG ratio constant, and hence the intracellular redox equilibrium.70,91 However, under milder oxidative stress conditions, total bile flow may not change

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While metformin has been demonstrated to improve mitochondrial respiration, it is worth noting that higher doses of metformin have been associated with a contrary effect, namely, reduced mitochondrial respiration

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