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Queval G, Thominet D, Vanacker H, Miginiac-Maslow M, Gakiere B, Noctor G

Breast Cancer Research , 6 (3), R149156

However, under conditions of stress and inhibition of the electron transport chain, the enzyme works in the opposite direction by transferring electrons from NADPH to NAD + , which impairs mitochondrial antioxidant defenses and feeds more reducing equivalents into the impaired electron transport chain leading to increased electron leakage and superoxide formation [133]