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The reaction mixture was cooled to rt and directly purified by flash silica gel column chromatography (0-70% EtOAc/hexanes) to afford the title compound

Accumulated literature suggests that fermented dairy products are one of the important sources of some nutritional biotics like probiotics, prebiotics, postbiotics and some bioactive metabolites

ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet

In rats, intravitreal injection of TNF- correlates with optic nerve degeneration and delayed death of retinal neuronal cells, associated with increased expression of NF-B p65 in the optic nerve, suggesting a link to TNF--induced axonal degeneration (165)