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NRF2s transcriptional activity requires its nuclear localisation and NRF2 is also degraded through binding to KEAP1, a process counteracted by competitive interaction of the latter protein with PALB2 and/or SQSTM1

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This is presumably due in part to ROS-induced oxidation of adenine (8-oxo-A) and guanine (8-oxo-G), which impairs DNA methylation patterns, since damaged bases in the nascent DNA strand can either inhibit the methylation of cytosine within a distance of 12 bp (base pairs) or the binding to the methyltransferase, thereby leading to global hypomethylation 132,133,134,135

Bergmann: A role for homoglutathione in organic sulphur transport to the developing mung bean seed