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In a follow-up study, mild-to-moderate gastrointestinal side effects, including nausea, abdominal pain, flatulence, and diarrhea, have been reported in participants who consume more than 1,000 mg/day of resveratrol for up to 29 consecutive days (11)

An early meta-analysis suggested that 3 g/day may be necessary to normalize serum ALT in a significant patient proportion (96), while other studies report benefits with 2 g/day on AST, ALT, and HOMA-IR ( at 900 mg/day improved AST, ALT, and HbA1c in diabetic NAFLD patients

10.1039/c5fo00480b 16

Thus far, CTR has not been predictable or directly related to the deteriorated condition of the valve flaps