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Clinical benefit rate was measured by determining the sum of the percentage of patients in Complete Remission (CR), the number of patients in Partial Remission (PR) and the number of patients with Stable Disease (SD) at a time point of at least 6 months from the end of therapy

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Matricellular proteins, including elastin, fibronectin 4, and fibronectin 5, are primarily expressed in the reticular layer 37,38 and are essential for the formation of elastic fibers