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As shown in Table 1 and Figure 6, in the pursuit of structurally diverse NNMT inhibitors, researchers have identified certain macrocyclic peptides that bind to NNMT, displaying potent inhibition with Half-maximal inhibitory concentration (IC 50 ) values as low as 229 nM (Van Haren et al., 2021)

doi:10.4103/1673-5374.213548 Borenstein R, Hanson BA, Markosyan RM, et al

Documented middle tier: Licensed compounding pharmacies following USP with lot-level benzyl alcohol and sterility confirmation

Many other commenters also emphasized the point that the cost of completing the survey would come at the expense of the hospital's ability to provide essential care to patients and quoted the GAO's 2006 report to the Congress in which the GAO concluded that the surveys it conducted created a considerable burden for hospitals and that to submit the required price data hospitals had to divert staff from their normal duties, thereby incurring additional costs. Many commenters stated that the financial burden of completing the survey would be exacerbated by upcoming Medicaid and Medicare reductions under the Inflation Reduction Act