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Lourenco, S., Oliveira, A

N.KohliI.Van Der PolW.ShaheenA.et al (2019)

Second line treatment was given to 6 patients, including FOLFOX (n=3) and ivosidenib (n=3)

However, it was puzzling that when comparing the active sites for the dimeric and tetrameric GAC species, there were no apparent differences in the positioning of the key catalytic residues, nor was there any indication of how the activation loops contributed to enzyme activity