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Ophthalmol Clin North Am 19(1):1324 Sharma A et al (2024) The ethanolic extract of chrysanthemum Morifolium Ramat flower activates Parasympathomimetic and anti-inflammatory effects for prevention of Presbyopia

The accumulation of NADH leads to a reduction in the coenzyme Q pool, and coupled with the malateaspartate shuttle, a surplus of fumarate accumulates and is then converted to succinate by the reverse catalysis of succinate dehydrogenase (SDH) [73, 74]

Activators At the transcriptional level, NFE2L2 gene is induced by several transcription factors, including the aryl hydrocarbon receptor (AhR) in response to environmental pollutants like polycyclic aromatic hydrocarbons, breast cancer susceptibility gene 1 (BRCA1) in response to xenobiotic stress, and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) in response to inflammatory stimuli

MECHANISM OF ACTION Acetaminophen is also known as N-acetyl-p-aminophenol