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Two groups were defined: 60 children with Down syndrome and 29 siblings without Down syndrome

Detox Strategies To support detoxification pathways in the presence of MTHFR mutations, consider the following strategies: Optimize nutrition: Focus on a nutrient-dense diet rich in antioxidants and vitamins that support methylation, such as B vitamins (B6, B12), folate (preferably in its active form, methylfolate), and glutathione-rich foods (e.g., cruciferous vegetables)

Vascular normalization seeks to transiently improve vessel structure and function, including pericyte coverage, perfusion, oxygenation and drug distribution [11, 12, 68]