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Although tesofensine did not have a significant effect on total 24-hour energy expenditure, it increased energy expenditure during the night period when adjusted for changes in body composition

As a 2025 comprehensive review by Jzwiak and colleagues in Pharmaceuticals (Basel) documents, BPC-157 was isolated from human gastric juice and has been studied in preclinical models since the early 1990s by a research group at the University of Zagreb

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