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10.14800/ttnd.243 199 KandelE

Thiele et al., 2022) and the Default Mode Network (DeSerisy et al., 2021

Glutamatergic signaling deficits are regarded as one of the earliest neurodevelopmental abnormalities associated with SCZ, with primary deficits in NMDA-R signaling, particularly in layer 3 pyramidal neurons in prefrontal cortex ( Finally, in consideration of the well-known role in motivation and incentive behavior, the DA hypothesis provides a reasonable neurobiological substrate to the salience hypothesis ( Dopaminergic Dysfunctions Relevant to Negative Symptoms As outlined above, NS are heterogeneous