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For instance, a study on hepatocellular carcinoma demonstrated that an 8-oxoG modification at the third position of miR-122 promotes tumorigenesis, whereas further oxidation of the second nucleotide to yield 2,3o8G-miR-122 transforms it into a tumor-suppressive miRNA

Pyruvate enters the mitochondria through mitochondrial pyruvate carriers 1 and 2 (MPC1 and 2), and their genetic depletion or pharmacologic inhibition reduces glucose-stimulated insulin secretion (GSIS) in rodent and human islets (Patterson et al., 2014