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Altered PTEN pathway expression has been found to enhance the efficacy of anti-PD-1 and anti-CTLA-4 antibodies in mouse models 60 and to improve the chemoresistance of breast cancer cells to DOX 61

doi: 10.4103/ijd.IJD_137_18 31

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The single greatest safety risk is not the compound itself but unverified sourcing: contamination, mislabeling, and inconsistent purity in the research peptide market make clinical supervision and verified supply chains non-negotiable